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KMID : 0061119820100000016
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Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.16 ~ p.16
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immunologic Monitoring of the Renal Transplant Recipients
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Bang, Byung-Kee
Kim, Ho-Youn/Kim, Hoon-Kyo/Kim, Choon-Choo/Kim, Dong-Jip/Min, Byong-Sok
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Abstract
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We performed E-rosette forming activities (E_(10 min) rosette, E_(20 hr) rosette), antibody dependent cell mediated cytotoxicity (ADCC) with recipient´s mononuclear cells as effector cells and chicken red blood cells as target cells, and natural killer cell mediated cytotoxicity (NKMC) with recipient´s mononuclear cells as effector cells and with K_(562) cells as target cells. These parameters were measured in cases of renal transplant recipients who were followed up at the Catholic Medical College. There was no significant correlation between E-rosette forming activities or ADCC and rejection process. NKMC in transplant recipients (22.22±3.3/16.0±2.41%) showed a significant decrease as compared with that of normal control (46.82±5.5/29.32±4.27%). The decrease began immediately and continued 6 years after transplantation. Although there was no evident correlation between NKMC activities and acute rejection, positive correlation. between long term graft function and NKMC activities, and also the difference of NKMC activities [(effector: target cells ratio (50:1)-(25:1)] could be observed.
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KEYWORD
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